Journal
CHEMICAL SOCIETY REVIEWS
Volume 42, Issue 13, Pages 5944-5962Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cs60077g
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Funding
- Royal Society and Parkinsons UK
- Marie Curie International Incoming Fellowship of the European Community's seventh Framework Programme [PIIF-GA-2010-271775]
- National Natural Science Foundation of China [21275087]
- Natural Science Foundation of Shandong Province of China [ZR2012BM008]
- Taishan Scholar Program of Shandong Province, China
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Electrical detection methodologies are likely to underpin the progressive drive towards miniaturised, sensitive and portable biomarker detection protocols. In being easily integrated within standard electronic microfabrication formats, and developing capability in microfluidics, the facile multiplexed detection of a range of proteins in a small analytical volume becomes entirely feasible with something costing just a few thousand pounds and benchtop or handheld in scale. In this review, we focus on recent important advances in label free assays of protein using a number of electrical methods, including those based on electrochemical impedance spectroscopy (EIS), amperometry/voltammetry, potentiometry, conductometry and field-effect methods. We introduce their mechanistic features and examples of application and sensitivity. The current state of the art, real world applications and challenges are outlined.
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