4.8 Review

Thiol-addition reactions and their applications in thiol recognition

Journal

CHEMICAL SOCIETY REVIEWS
Volume 42, Issue 14, Pages 6032-6059

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cs60055f

Keywords

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Funding

  1. National Natural Science Foundation of China [21072119, 21102086]
  2. Shanxi Province Science Foundation for Youths [2012021009-4]
  3. Shanxi Province Foundation for Returnee [2012-007]
  4. Taiyuan Technology star special [12024703]
  5. Shanxi Province Foundation for Selected Returnees [2010]
  6. CAS Key Laboratory of Analytical Chemistry for Living Biosystems Open Foundation [ACL201304]
  7. Spanish Government [MAT2012-38429-C04-01]
  8. Generalitat Valencia [PROMETEO/2009/016]

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Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes.

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