Journal
CHEMICAL SOCIETY REVIEWS
Volume 42, Issue 13, Pages 5788-5808Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cs60042d
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Funding
- NHLBI NIH HHS [R21 HL095960, R21 HL112114] Funding Source: Medline
- NIAID NIH HHS [R01 AI081534, R21 AI087107, R01 AI093282] Funding Source: Medline
- NIBIB NIH HHS [R01 EB015776, U54 EB015408] Funding Source: Medline
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Recent technological advances provide new tools to manipulate cells and biological agents in micro/nanoliter volumes. With precise control over small volumes, the cell microenvironment and other biological agents can be bioengineered; interactions between cells and external stimuli can be monitored; and the fundamental mechanisms such as cancer metastasis and stem cell differentiation can be elucidated. Technological advances based on the principles of electrical, magnetic, chemical, optical, acoustic, and mechanical forces lead to novel applications in point-of-care diagnostics, regenerative medicine, in vitro drug testing, cryopreservation, and cell isolation/purification. In this review, we first focus on the underlying mechanisms of emerging examples for cell manipulation in small volumes targeting applications such as tissue engineering. Then, we illustrate how these mechanisms impact the aforementioned biomedical applications, discuss the associated challenges, and provide perspectives for further development.
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