Journal
CHEMICAL SOCIETY REVIEWS
Volume 42, Issue 10, Pages 4310-4326Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cs35401b
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Funding
- National Creative Research Initiative
- WCU
- NIH
- NCI
- Benzon Foundation
- Danish Agency for Science
- EU [215536]
- EU FP7-GlycoBioM
- Danish National Research Foundation
- University of Copenhagen Programme of Excellence
- National Research Foundation of Korea [R32-2012-000-10217-0, 2010-0018272] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray-based technology has been widely employed for rapid analysis of the glycan binding properties of lectins and antibodies, the quantitative measurements of glycan-protein interactions, detection of cells and pathogens, identification of disease-related anti-glycan antibodies for diagnosis, and fast assessment of substrate specificities of glycosyltransferases. This review covers the construction of carbohydrate microarrays, detection methods of carbohydrate microarrays and their applications in biological and biomedical research.
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