Journal
CHEMICAL SOCIETY REVIEWS
Volume 41, Issue 10, Pages 3912-3928Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cs15331a
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Funding
- National Center for Research Resources [5P41RR018522-10]
- National Institute of General Medical Sciences [8 P41 GM103493-10]
- National Cancer Institute from the National Institutes of Health [U24-CA-160019-01]
- Pacific Northwest National Laboratory
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Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for identification, characterization, and quantification of proteins that are integral components of the processes essential for life. Characterization of proteins at the proteome and sub-proteome (e. g., the phosphoproteome, proteoglycome, or degradome/peptidome) levels provides a foundation for understanding fundamental aspects of biology. Emerging technologies such as ion mobility separations coupled with MS and microchip-based-proteome measurements combined with MS instrumentation and chromatographic separation techniques, such as nanoscale reversed phase liquid chromatography and capillary electrophoresis, show great promise for both broad undirected and targeted highly sensitive measurements. MS-based proteomics increasingly contribute to our understanding of the dynamics, interactions, and roles that proteins and peptides play, advancing our understanding of biology on a systems wide level for a wide range of applications including investigations of microbial communities, bioremediation, and human health.
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