Journal
CHEMICAL SOCIETY REVIEWS
Volume 41, Issue 10, Pages 3790-3807Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cs15356d
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Funding
- Fund for Scientific Research (FWO), Flanders
- University of Leuven (KU Leuven)
- EMECW (Triple I)
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In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an alkyne and an amine, commonly called A(3)-coupling, has been established as a convenient and general approach towards propargylamines. Furthermore, the A(3)-coupling has found a broad application as a key step in the construction of various nitrogen-containing heterocycles, biologically active compounds and natural products. Several interesting modifications of the A(3)-coupling as well as different tandem reactions involving A(3)-coupling have been developed. This tutorial review aims to highlight the current achievements in the field of A(3)-couplings and related transformations.
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