Journal
CHEMICAL SOCIETY REVIEWS
Volume 40, Issue 1, Pages 233-245Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cs00003e
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Funding
- Canadian Institute of Health Research
- Natural Sciences and Engineering Research Council (NSERC)
- Canadian Foundation for Innovation
- Ministry of Research and Innovation
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The ability to target contrast agents and therapeutics inside cells is becoming important as we strive to decipher the complex network of events that occur within living cells and design therapies that can modulate these processes. Nanotechnology researchers have generated a growing list of nanoparticles designed for such applications. These particles can be assembled from a variety of materials into desirable geometries and configurations and possess useful properties and functionalities. Undoubtedly, the effective delivery of these nanomaterials into cells will be critical to their applications. In this tutorial review, we discuss the fundamental challenges of delivering nanoparticles into cells and to the targeted organelles, and summarize strategies that have been developed to-date.
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