Journal
CHEMICAL SOCIETY REVIEWS
Volume 40, Issue 12, Pages 5771-5788Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15014f
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Funding
- National Institute of General Medical Sciences, National Institutes of Health [R01 GM088697]
- Idaho NSF EPSCoR
- University of Idaho Biological Applications of Nanotechnology (BANTech) Center
- Institute of Translational Health Sciences (ITHS)
- NIH National Center for Research Resources [UL1 RR025014, KL2 RR025015, TL1 RR025016, P20 RR016454]
- United States Department of Agriculture [2009-34479-19833]
- NATIONAL CENTER FOR RESEARCH RESOURCES [TL1RR025016, P20RR016454, UL1RR025014, KL2RR025015] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM088697] Funding Source: NIH RePORTER
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Pyrene-functionalized oligonucleotides (PFOs) are increasingly explored as tools in fundamental research, diagnostics and nanotechnology. Their popularity is linked to the ability of pyrenes to function as polarity-sensitive and quenchable fluorophores, excimer-generating units, aromatic stacking moieties and nucleic acid duplex intercalators. These characteristics have enabled development of PFOs for detection of complementary DNA/RNA targets, discrimination of single nucleotide polymorphisms (SNPs), and generation of pi-arrays on nucleic acid scaffolds. This critical review will highlight the physical properties and applications of PFOs that are likely to provide high degree of positional control of the chromophore in nucleic acid complexes. Particular emphasis will be placed on pyrene-functionalized Locked Nucleic Acids (LNAs) since these materials display interesting properties such as fluorescence quantum yields approaching unity and recognition of mixed-sequence double stranded DNA (144 references).
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