Journal
CHEMICAL SOCIETY REVIEWS
Volume 40, Issue 10, Pages 5010-5029Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15075h
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- Novartis International AG
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Until recently, cross-coupling reactions have been exclusively performed in batch processes. With the advent of microfluidics, significant effort has been devoted to develop a wide variety of continuous-flow techniques to facilitate organic synthesis. In this critical review, we attempt to give an overview of the different continuous-flow methodologies that have been developed and utilized for cross-coupling reactions. In addition, we attempt to point out the advantages of continuous-flow when compared with their batch counterparts (246 references).
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