Journal
CHEMICAL SOCIETY REVIEWS
Volume 40, Issue 12, Pages 5910-5921Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15212b
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Funding
- Deutsche Forschungsgemeinschaft (DFG)
- Bundesministerium fur Bildung und Forschung (BMBF)
- Alexander-von-Humboldt Stiftung
- European Union
- Max-Planck Society
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Proteins possess intrinsic functionalities, which have been optimized in billions of years of natural evolution. The conjugation of proteins with artificial nucleic acids allows one to further functionalize proteins with a synthetically accessible, physicochemically robust tag, which is addressable in a highly specific manner by Watson-Crick hybridization. The resulting DNA-protein conjugates can be advantageously used in a variety of applications, ranging from biomedical diagnostics to DNA-based nanofabrication. This critical review provides an overview on chemical approaches to the synthesis of DNA-protein conjugates and their applications in biomolecular nanosciences (96 references).
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