Journal
CHEMICAL SOCIETY REVIEWS
Volume 40, Issue 9, Pages 4591-4602Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cs15020k
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- Georgia Cancer Coalition (GCC) Distinguished Cancer Clinicians and Scientists
- US National Science Foundation [NSF MCB-0824837]
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X-ray crystallography has proven to be an essential tool for structural studies of bio-macromolecules at the atomic level. There are two major bottle-neck problems in the macromolecular crystal structure determination: phasing and crystallization. Although the selenium derivatization is routinely used for solving novel protein structures through the MAD phasing technique, the phase problem is still a critical issue in nucleic acid crystallography. The background and current progress of using direct selenium-derivatization of nucleic acids (SeNA) to solve the phase problem and to facilitate nucleic acid crystallization for X-ray crystallography are summarized in this tutorial review.
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