Journal
CHEMICAL SOCIETY REVIEWS
Volume 39, Issue 3, Pages 1060-1072Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b900409m
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Funding
- National Science Foundation [DMI-0328162, CTS-0120978]
- Department of Energy [DE FG02 07ER15851]
- Strategic Environmental Research and Development Program [W9132T-05-2-0028]
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Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).
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