Journal
CHEMICAL SOCIETY REVIEWS
Volume 39, Issue 9, Pages 3371-3379Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b919452p
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Funding
- Australian Research Council
- National Heart Foundation
- National Health AMP
- Medical Research Council
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Elastin is a versatile elastic protein that dominates flexible tissues capable of recoil, and facilitates commensurate cell interactions in these tissues in all higher vertebrates. Elastin's persistence and insolubility hampered early efforts to construct versatile biomaterials. Subsequently the field has progressed substantially through the adapted use of solubilized elastin, elastin-based peptides and the increasing availability of recombinant forms of the natural soluble elastin precursor, tropoelastin. These interactions allow for the formation of a sophisticated range of biomaterial constructs and composites that benefit from elastin's physical properties of innate assembly and elasticity, and cell interactive properties as discussed in this tutorial review.
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