4.8 Review

Fluorogenic click reaction

Journal

CHEMICAL SOCIETY REVIEWS
Volume 39, Issue 4, Pages 1233-1239

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b901975h

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Funding

  1. US NSF [CHE-0748690, DMR-0706431]
  2. US-Army [W911NF-09-0236]
  3. Alfred P. Sloan Scholarship
  4. Camille Dreyfus Teacher Scholar Award
  5. W. M. Keck Foundation

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Fluorogenic Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions have emerged as a powerful tool for bioconjugation, materials science, organic synthesis and drug discovery. This review highlights the design of the recent development of fluorogenic CuAAC reactions as well as their applications.

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