Journal
CHEMICAL SOCIETY REVIEWS
Volume 39, Issue 5, Pages 1600-1632Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b923537j
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Funding
- National Science Foundation
- National Institutes of Health [GM-13598, GM-33049]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM013598, R01GM033049, R01GM013598] Funding Source: NIH RePORTER
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Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets ( 357 references).
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