Journal
CHEMICAL SOCIETY REVIEWS
Volume 38, Issue 8, Pages 2360-2384Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b813796j
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Funding
- UCL Chemistry
- EPSRC [EP/D030005]
- Royal Society (SH)
- National Science Foundation [CHE 0747237]
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In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).
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