Journal
CHEMICAL SOCIETY REVIEWS
Volume 37, Issue 2, Pages 320-330Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b610213c
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It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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