Journal
CHEMICAL SOCIETY REVIEWS
Volume 37, Issue 7, Pages 1294-1307Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b703023c
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072600] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM072600, R01 GM072600-01A1] Funding Source: Medline
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Embryogenesis is a remarkable program of cell proliferation, migration, and differentiation that transforms a single fertilized egg into a complex multicellular organism. Understanding this process at the molecular and systems levels will require an interdisciplinary approach, including the concepts and technologies of chemical biology. This tutorial review provides an overview of chemical tools that have been used in developmental biology research, focusing on methods that enable spatiotemporal control of gene function and the visualization of embryonic patterning. Limitations of current approaches and future challenges are also discussed.
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