Journal
CHEMICAL SENSES
Volume 36, Issue 1, Pages 9-17Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjq081
Keywords
genetics; odorants; olfaction; psychophysics; specific anosmia
Funding
- Monell Chemical Senses Center
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R03DC003509, R01DC004698] Funding Source: NIH RePORTER
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The urine of people who have recently eaten asparagus has a sulfurous odor, which is distinct and similar to cooked cabbage. Using a 2-alternative forced-choice procedure, we examined individual differences in both the production of the odorants and the perception of this asparagus odor in urine. We conclude that individual differences exist in both odorant production and odor perception. The biological basis for the inability to produce the metabolite in detectable quantities is unknown, but the inability to smell the odor is associated with a single nucleotide polymorphism (rs4481887) within a 50-gene cluster of olfactory receptors.
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