Journal
CHEMICAL REVIEWS
Volume 118, Issue 18, Pages 9412-9454Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00767
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Funding
- University of Washington
- University of Washington Royalty Research Fund
- Burroughs-Wellcome Award at the Scientific Interface
- NIH [R01MH115767]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH115767] Funding Source: NIH RePORTER
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The past decade has witnessed an explosion in the use of super resolution fluorescence microscopy methods in biology and other fields. Single molecule localization microscopy (SMLM) is one of the most widespread of these methods and owes its success in large part to the ability to control the on-off state of fluorophores through various chemical, photochemical, or binding-unbinding mechanisms. We provide here a comprehensive overview of switchable fluorophores in SMLM including a detailed review of all major classes of SMLM fluorophores, and we also address strategies for labeling specimens, considerations for multichannel and live-cell imaging, potential pitfalls, and areas for future development.
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