Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 27, Issue 2, Pages 172-174Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx400454z
Keywords
-
Funding
- MIT Center for Environmental Health Sciences through NIEHS [P30 ES002109]
- UNC Center for Environmental Health and Susceptibility by NIEHS [P30 ES010126]
- UGA
Ask authors/readers for more resources
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available