Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 27, Issue 6, Pages 949-951Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx5001333
Keywords
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Funding
- Canadian Institutes of Health Research
- Canada Research Chair in Adverse Drug Reactions
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Chemically reactive drugs and drugs that form reactive metabolites often cause idiosyncratic drug reactions (IDRs); however, not all such drugs are associated with IDRs. Most IDRs appear to be immune mediated; therefore, the ability of a drug to induce an immune response may be the determinant of which drugs will cause IDRs. lnflammasome activation plays an important role in the initiation of an immune response. In this study, we studied two pairs of similar chemically reactive drugs, telaprevir/boceprevir and dimethyl fumarate/ethacrynic acid. In both pairs, the drug associated with skin reactions activated inflammasomes in THP-1 cells, and the drug not associated with skin reactions did not.
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