Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 24, Issue 4, Pages 478-480Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx200060c
Keywords
-
Funding
- GIL [200710.0028]
- NIH [DK056350]
- Czech Science Foundation [203/09/1783]
- IAC ASCR [AV0Z40310501]
Ask authors/readers for more resources
Growing evidence suggest that the methylated trivalent metabolites of inorganic arsenic (iAs), methylarsonite (MAsIII) and dimethylarsinite (DMAsIII), contribute to adverse effects of iAs exposure. However, the lack of suitable methods has hindered the quantitative analysis of MAsIII and DMAsIII in complex biological matrices. Here, we show that hydride generation-cryotraging-atomic absorption spectrometry can quantify both MAsIII and DMAsIII in livers of mice exposed to iAs. No sample extraction is required, thus limiting MAsIII or DMAsIII oxidation prior to analysis. The limits of detection are below 6 ng As/g of tissue, making this method suitable even for studies examining low exposures to iAs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available