Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 23, Issue 6, Pages 1001-1008Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx100056m
Keywords
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Funding
- National Institutes of Health [CA-81301, CA-85702, CA-92025, CA-129534, DA-13333, ES-11297, NO1-CP-64402]
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Tobacco carcinogen and toxicant biomarkers arc metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.
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