Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 23, Issue 8, Pages 1307-1309Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx100187f
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Funding
- Ruth L. Kirschstein National Research Service [T32 CA9686]
- NW [CA100853]
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We show that naturally occurring isothiocyanates (ITCs) sensitize human non-small cell lung cancer cells to cisplatin. Moreover, the structure of the ITC side chain moiety is important for sensitization. In NCI-H596 cells, 20 mu M benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC) enhance the efficacy of various concentrations of cisplatin, but sulforaphane (SFN) does not. Reducing the concentration of BITC and PEITC to 10 mu M still allows for the sensitization of cells to cisplatin. Neither cellular platinum accumulation nor DNA platination account for this increased cytotoxicity. BITC and PEITC deplete beta-tubulin, but SFN does not; this correlates with and may be important for sensitization.
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