Lead Detoxification Activity and ADMET Hepatotoxicity of N-(α-L-Arabino-furanos-1-yl)-L-cysteine

N-(alpha-L-Arabinofuranos-l-y1)-L-cysteine was stereoselectively prepared from L-arabinose and L-cysteine. Its in viva detoxification action was evaluated on lead loaded mice at the doses of 0.1, 0.2, and 0.4 mmol/kg. The results show that lead accumulation in the livers, kidneys, brains, and femurs of the treated mice could be efficiently decreased by N-(alpha-L-arabinofuranos-1-yl)-L-cysteine, even at the dose of 0.1 mmol/kg. Compared with the lead detoxification efficacy, 0.4 mmol/kg of N-(alpha-L-arabinofuranos-1-yl)L-cysteine did not affect the essential metals in the treated mice, such as Fe, Cu, Zn, and Ca. In the apparent permeability coefficient test, the values of P-app(A -> B), P-app(B -> A), and P-app(A -> B)/P-app(B -> A) indicated that N-(alpha-L-arabinofuranos-1-yl)-L-cysteine was transported actively across the Caco-2 cell monolayer. Silico molecular modeling results predicted that N-(alpha-L-arabinofuranos-1-yl)-L-cysteine had no hepatotoxicity.