Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 21, Issue 1, Pages 232-252Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx700292a
Keywords
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Funding
- NCI NIH HHS [R01 CA080024, R01 CA080024-06, R01 CA080024-03, R01 CA080024-08, R01 CA086061-07, R01 CA080024-04, P01 CA026731-260010, R01 CA080024-09, P01 CA026731-250010, R01 CA086061-07S1, P01 CA026731-307986, R37 CA080024, R01 CA080024-07, R01 CA080024-02, CA26731, P01 CA026731-280010, P01 CA026731, CA80024, P01 CA026731-317986, R01 CA080024-05, R01 CA086061, R01 CA080024-10, P01 CA026731-290010, P01 CA026731-270010] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA080024, P01CA026731, R01CA086061, R37CA080024] Funding Source: NIH RePORTER
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The genome and its nucleotide precursor pool are under sustained attack by radiation, reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and certain drugs. As a result, a large and heterogeneous population of damaged nucleotides forms in all cells. Some of the lesions are repaired, but for those that remain, there can be serious biological consequences. For example, lesions that form in DNA can lead to altered gene expression, mutation, and death. This perspective examines systems developed over the past 20 years to study the biological properties of single DNA lesions.
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