Journal
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Volume 30, Issue 3, Pages 390-395Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-014-3491-6
Keywords
1,2,3-Thiadiazole; 1,2,4-Triazole; Insecticidal activity; Anti-tobacco mosaic virus(TMV) activity
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Funding
- National Key Technology Research and Development Program of China [2011BAE06B02]
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A series of novel 1,2,4-triazole derivatives containing 1,2,3-thiadiazole ring was designed and synthesized. Their structures were confirmed by IR, H-1 NMR, high resolution mass spectrometer(HRMS) and electrospray ionization-mass spectrometer(ESI-MS) combined with melting points and elemental analysis. Preliminary bioassays indicate that these compounds exhibit good insecticidal activity against Aphis laburni at 100 mu g/mL, especially compound 6b shows mortality of no less than 95%. Most of the compounds show good activities against tobacco mosaic virus(TMV) with different modes in vivo at 100 mu g/mL. Compound 6d standed out, showing a good insecticidal activity and very high induction effects against TMV in vivo. Collectively, our data demonstrate a new strategy for insect and virus control.
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