Journal
CHEMICAL RECORD
Volume 8, Issue 3, Pages 129-142Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/tcr.20144
Keywords
diversity-oriented synthesis (DOS); combinatorial chemistry; library synthesis; chemical space; skeletal diversity
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Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what can be achieved using the DOS approach to library generation. We describe some of the most successful strategies utilized in DOS, with special focus on our own area of interest; DOS from simple, pluripotent starting materials. (c) 2008 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.
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