Journal
CHEMICAL PHYSICS LETTERS
Volume 501, Issue 1-3, Pages 113-117Publisher
ELSEVIER
DOI: 10.1016/j.cplett.2010.10.048
Keywords
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Funding
- National Natural Science Foundation of China [20633060, 20873075]
- Independent Innovation Foundation of Shandong University [2009JC018]
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A ribosome is a large RNA-protein machine that catalyzes protein synthesis. RNA plays a crucial role in catalyzing peptide bond formation. In this Letter, we focus on the catalytic role of the A76 2'-OH of the P site in tRNA. Three possible reaction schemes were compared using the same reaction model and theoretical level. By comparison of the potential energy surface and optimized geometries of transition states, a new favorable reaction pathway is shown. The activation energy is 24.0 kcal/mol. This work will provide a foundation for further theoretical and experimental study of ribosome mechanisms. (C) 2010 Elsevier B. V. All rights reserved.
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