Journal
CHEMICAL PHYSICS LETTERS
Volume 480, Issue 1-3, Pages 113-117Publisher
ELSEVIER
DOI: 10.1016/j.cplett.2009.08.052
Keywords
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20034056]
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [20034056] Funding Source: KAKEN
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Protamine, an arginine-rich protein, is essential for the compaction of sperm DNA. We performed single-molecule observations of DNA double-strand breaks caused by Co-60 gamma-ray irradiation and quantitatively evaluated the protective effect of protamine. It was shown that double-strand breaks were significantly protected for the tightly compact DNA, whereas there is no apparent decrease on the damage for loosely aggregated DNA molecules. Our findings suggest that the densely packed structure of DNA reduces the ability of radiolytic reactive oxygen species to access DNA and thus protects DNA from double-strand breaks. (C) 2009 Elsevier B.V. All rights reserved.
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