Journal
CHEMICAL PHYSICS
Volume 350, Issue 1-3, Pages 179-185Publisher
ELSEVIER
DOI: 10.1016/j.chemphys.2008.02.005
Keywords
non-steroidal anti-inflammatory drug; piroxicam; femtosecond; ultrafast dynamics; proton transfer; twisting motion; viscosity; transient absorption; stimulated emission; potential-energy surfaces
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In this contribution, we report on fast and ultrafast dynamics of a non-steroidal anti-inflammatory drug, piroxicam (PX), in methyl acetate (MAC) and triacetin (TAC), two solvents of different viscosities. The enol form of PX undergoes a femtosecond (shorter than 100 fs) electronically excited state intramolecular proton-transfer reaction to produce keto tautomers. These structures exhibit an internal twisting motion to generate keto rotamers in similar to 2-5 ps, a time being longer in TAC. The transient absorption/emission spectrum is very broad indicating that the potential-energy surface at the electronically excited state is very flat, and reflecting the involvement of several coordinates along which the wavepacket of the fs-produced structures evolve. (C) 2008 Elsevier B.V. All rights reserved.
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