Journal
CHEMICAL GEOLOGY
Volume 265, Issue 3-4, Pages 420-431Publisher
ELSEVIER
DOI: 10.1016/j.chemgeo.2009.05.010
Keywords
Mass spectrometry; Double spike; Optimisation; Fractionation correction
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The double spike technique is a well established method for correcting for instrumental mass fractionation in mass spectrometry. The precision of the technique is controlled by the choices of double spike composition and the proportions in which the double spike and sample are mixed. To make these choices easier, we provide software (the double spike toolbox) for calculating optimal double spikes, which are chosen purely on the basis of minimising error propagation. In addition, we provide cocktail lists of optimal double spikes for all 33 elements that have 4 or more naturally occurring isotopes, using some sensible default parameters. As examples, we discuss the application of the software to Fe, Pb, and Ca isotopes. (C) 2009 Elsevier B.V. All rights reserved.
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