Flow and mixing analysis of non-Newtonian fluids in straight and serpentine microchannels

Numerical simulations were carried out to investigate the flow dynamics and mixing behavior in T-shaped and serpentine microchannels with non-Newtonian working fluids using shear-dependent viscosity models. As an illustrative case study, the microfluidic transport of blood was considered. The Carreau-Yasuda and Casson non-Newtonian blood viscosity models were used to capture the non-Newtonian characteristics. Steady Navier-Stokes equations with a diffusion-convection model for species concentration were solved in flow and mixing analyses. Under similar operating conditions, flow dynamics and mixing were compared between the working fluids: water (a Newtonian fluid), and blood using the Carreau-Yasuda non-Newtonian model. For a mass flow rate of (m) over dot < 10(-2) kg/h, the mixing performances of both the fluids were found to be nearly equivalent, and decreased with flow rate. With increased flow rate, the mixing with water was significantly improved. However, a negligible change in mixing performance was observed using the Carreau-Yasuda model for blood. Also, the pumping power needed was considerably higher for the blood sample (similar to 1 bar) than for water (similar to 0.40 bar) at the same flow rate. The mixing behavior with the Carreau-Yasuda blood model was compared for T-shaped and serpentine channels over a fixed mixing length. The serpentine channel showed better mixing performance over the flow rate range considered. (C) 2014 Elsevier Ltd. All rights reserved.