Journal
CHEMICAL ENGINEERING SCIENCE
Volume 84, Issue -, Pages 552-556Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2012.08.054
Keywords
Cefalexin; Multi-walled carbon nanotubes; Nanostructure; Antimicrobial property; Immobilization Poly(ethylene glycol)
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Funding
- Environment and Water Industry Programme Office (EWI) - National Research Foundation Singapore [0802-IRIS-12]
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Multi-walled carbon nanotubes (MWNTs) possess weak antimicrobial property. In this report, we demonstrate that the covalent immobilization of the antibiotic cefalexin via poly(ethylene glycol) as a linking agent improves the antimicrobial and anti-adhesive properties of MWNTs against both Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis). In particular, the MWNT-cefalexin composite showed 2-fold higher antimicrobial property than pristine MWNTs against S. aureus and B. subtilis. Moreover, the MWNT-cefalexin deposited film effectively inhibited cell adhesion. Given the simple, inexpensive procedures of our synthesis method, the MWNT-cefalexin composite has the potential to be used as an effective and economical antibacterial and anti-adhesion material for environmental and biomedical applications. (C) 2012 Elsevier Ltd. All rights reserved.
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