Journal
CHEMICAL ENGINEERING SCIENCE
Volume 77, Issue -, Pages 112-121Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2012.01.047
Keywords
Crystallization; Process control; Particulate processes; Phase change; Oiling out; Supersaturation
Categories
Funding
- Science Foundation Ireland [07/SRC/B1158]
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The oiling out and crystallization behavior of a pharmaceutical compound from acetone and water was studied using a range of in-situ tools to qualitatively describe the oiling out phenomenon. Using a single peak height in the IR spectral region, the liquid phase concentration could be tracked during the liquid-liquid phase separation and also during the subsequent crystallization. This allowed the oiling out region of the system to be properly understood at a mechanistic level and also allowed for the implementation of a control technique that would control the particle size over regular seeding and maintain supersaturation at a constant level. (C) 2012 Elsevier Ltd. All rights reserved.
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