Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 26, Pages 7684-7687Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503042
Keywords
asymmetric catalysis; copper; dearomatization; heterocycles; synthetic methods
Categories
Funding
- National Basic Research Program of China (973 Program) [2015CB856600]
- NSFC [21332009, 21421091]
- Chinese Academy of Sciences
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The first copper-catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86% yield and 98% ee.
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