Journal
CHEMICAL ENGINEERING JOURNAL
Volume 137, Issue 1, Pages 45-53Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2007.07.088
Keywords
silica particles; drug delivery; pegylation; MCM-41; MCM-48; biodegradability; BSA adsorption; PEG
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Bare and PEGylated silica spheres have been synthesized and characterized in order to study their potential application as intravenous drug-delivery vectors. Solubility under physiological conditions (in simulated body fluid) as well as standard protein adsorption experiments (immobilization of bovine serum albumin, BSA) were carried out in order to analyze the stability and the potential avoidance of the reticuloendothelial system (RES) achieved after PEGylation. The influences of the chain length of the PEG, as well as, of the temperature in the esterification reaction were also analyzed. (C) 2007 Elsevier B.V. All rights reserved.
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