Journal
ACS CHEMICAL NEUROSCIENCE
Volume 6, Issue 3, Pages 380-385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cn500248u
Keywords
Lipoic acid; trigeminal pain; antiallodynic agents; TRP channels
Funding
- Ministero dell'Istruzione, dell'Universita e della Ricerca [01_00937]
- Ente Cassa di Risparmio di Firenze (ECR)
- Cassa di Risparmio di Firenze
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Inflammation of the trigeminal nerve is considered one of the most painful conditions known to humankind. The diagnosis is often difficult; moreover, safe and effective pharmacological treatments are lacking. A new molecule, ADM_12, formed by a lipoic and omotaurine residues covalently linked, is here reported. In vitro and in vivo tests showed that ADM_12 is a very attractive original compound presenting (i) a remarkable safety profile; (ii) a high binding constant versus TRPA1; (iii) an intriguing behavior versus TRPV1; and (iv) the ability to significantly and persistently reduce mechanical facial allodynia in rats. Noteworthy, by testing ADM_12, we shed light on the unprecedented involvement of TRPA1 and TRPV1 channels in orofacial pain.
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