4.7 Article

Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 83, Pages 11701-11704

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06966b

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Funding

  1. NCI NIH HHS [R21 CA199744] Funding Source: Medline
  2. NIGMS NIH HHS [P41 GM103493] Funding Source: Medline

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To address the challenges associated with glycan analyses, we have implemented a structures for lossless ion manipulations (SLIM) serpentine ultra-long path with extended routing (SUPER) ion mobility-mass spectrometry (i.e. SLIM SUPER IM-MS) platform to achieve much higher resolution of isomeric glycoforms. We have demonstrated the potential of this platform as a future component of the glycomics toolbox.

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