Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 82, Pages 11606-11609Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06838k
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Perturbations of domain-domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain-domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.
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