Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 77, Pages 10897-10900Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05525d
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Funding
- National Natural Science Foundation of China [51473136, 21575116, 21675129, 21775124]
- Fundamental Research Funds for the Central Universities, China [XDJK2016E055]
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Herein, an adenosine triphosphate (ATP)-fueled nucleic acid signal amplification strategy based on toehold-mediated strand displacement (TMSD) and fluorescence resonance energy transfer (FRET) was proposed for highly sensitive detection of microRNA-21. More importantly, the target microRNA-21 could be regenerated with ATP as the fuel rather than a nucleotide segment in conventional approaches, which made the proposed strategy simple and efficient due to the high affinity and strength of the aptamer-target interaction.
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