Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 77, Pages 10878-10881Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04635b
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Funding
- Kong Research Grant Council [CityU 21302317, N_CityU110/17]
- Croucher Foundation [9500030]
- City University of Hong Kong [9610363, 7200520]
- Hong Kong Health and Medical Research Fund [03141186]
- Hong Kong Research Grants Council [21106616]
- Natural Science Foundation of China [81602514, 81773246]
- MRC Strategic Alliance Funding [MC_UU_12025]
- Petroleum Technology Development Fund from Nigerian government
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Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA-mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation.
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