Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 69, Pages 9647-9650Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03945c
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Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
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