Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 76, Pages 10718-10721Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06010j
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Funding
- European Research Council (ERC) through the grant FOLDHALO [307108]
- CARIPLO Foundation [2014-0746, 2016-0472]
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Herein we report a halogen bond-donor amino acid, 4-iodotetrafluorophenylalanine, which behaves as a catalyst for the aqueous synthesis of bis-(heterocyclic)methanes. We also provide experimental evidence that halogen bonding is a plausible explanation for the observed catalytic effect.
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