Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 75, Pages 10574-10577Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04907f
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A method for the direct C(sp(2))-H trifluoromethylation of enamides, including biologically relevant isoindolinones, isoquinolinones and 2-pyridinones using TMSCF3 under oxidative conditions is presented. The protocol is convenient, operationally simple and exhibits high tolerance across a multitude of relevant handles and functional groups.
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