4.7 Article

Hairpin-fuelled catalytic nanobeacons for amplified microRNA imaging in live cells

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 73, Pages 10336-10339

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06298f

Keywords

-

Funding

  1. Key Project of the National Natural Science Foundation of China [21735002]
  2. Foundation for Innovative Research Groups of NSFC [21521063]
  3. National Natural Science Foundation of Hunan Province [2017JJ2039]
  4. Fundamental Research Funds for the Central Universities

Ask authors/readers for more resources

Direct imaging of low-abundance RNAs in live cells remains challenging because of the relatively low sensitivity of conventional molecular imaging probes. Here, we introduce hairpin-fuelled catalytic nanobeacons for microRNA (miRNA) imaging in live cells with signal amplification capacity. Compared with the conventional nanobeacons in solution, the catalytic nanobeacons could generate two orders of magnitude higher sensitivity.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available