Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 73, Pages 10336-10339Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc06298f
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Funding
- Key Project of the National Natural Science Foundation of China [21735002]
- Foundation for Innovative Research Groups of NSFC [21521063]
- National Natural Science Foundation of Hunan Province [2017JJ2039]
- Fundamental Research Funds for the Central Universities
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Direct imaging of low-abundance RNAs in live cells remains challenging because of the relatively low sensitivity of conventional molecular imaging probes. Here, we introduce hairpin-fuelled catalytic nanobeacons for microRNA (miRNA) imaging in live cells with signal amplification capacity. Compared with the conventional nanobeacons in solution, the catalytic nanobeacons could generate two orders of magnitude higher sensitivity.
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