Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 68, Pages 9442-9445Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03614d
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Funding
- NATIONAL CANCER INSTITUTE [R01CA153821] Funding Source: NIH RePORTER
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This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.
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