Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 67, Pages 9286-9289Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04530e
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Funding
- National Institute of Health [RO1 GM106180]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM106180] Funding Source: NIH RePORTER
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Antimicrobial functionality is introduced into a pharmaceutical formulation of miconazole while improving solubility. The work leverages hydrate formation propensity in order to produce hydrogen peroxide solvates. The ubiquity of hydrate formation suggests that hydrogen peroxide can be broadly deployed in pharmaceuticals, rendering a liquid excipient suitable for solid pharmaceutical formulations.
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