Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 67, Pages 9309-9312Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05687k
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Funding
- CSIR Mission Mode Project on Nano-biosensors and Microfluidics for Healthcare
- UGC, India
- ICMR, India
- CSIR, India
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A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a MMP9 enzymatic site. Interestingly, it has a propensity to encapsulate and deliver the doxorubicin drug specifically to the cancer cell, induces superior apoptotic death, and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids.
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